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MessagePosté le: Ven 20 Mai - 20:18 (2016)    Sujet du message: Nature Reviews Genetics Npg-147-1-0064 Répondre en citant




Nature Reviews Genetics Npg 1471-0064 > urlin.us/2bp4c





All,,,Rights,,,ReservedDespite,,the,,sequence,,similarity,,between,,primates,,,comparisons,,among,,members,,of,,this,,clade,,are,,beginning,,to,,identify,,primate-,,as,,well,,as,,human-specific,,functional,,elementsAll,,Rights,,Reserved.Genetics,Conferences,A,calendar,of,forthcoming,meetings,and,workshops,from,across,the,field,of,genetics,and,genomicsThis,,,collection,,,provides,,,a,,,comprehensive,,,bench-to-bedside,,,overview,,,of,,,cancer,,,genomicsJumptomaincontent,,Jumptonavigation,,nature.com,,homepage,,PublicationsA-ZindexBrowsebysubject,,My,,accountE-alert,,sign,,up,,RegisterSubscribe,,LoginCart,,Search,,Advancedsearch,,Home,,>,,About,,the,,journal,,About,,the,,journal,,About,,the,,journal,,Journal,,scope,,Contacts,,and,,staff,,About,,the,,editors,,Impact,,factor,,Conferences,,Top,,of,,page,,Main,,navigation,,Journal,,contentJournal,,homeAdvance,,online,,publicationCurrent,,issueArchiveWeb,,FocusesSupplementsArticle,,SeriesMultimediaPosters,,Journal,,informationGuide,,to,,Nature,,Reviews,,GeneticsOnline,,submissionGuidelines,,for,,refereesAbout,,the,,journalJournal,,scopeContacts,,and,,staffAbout,,the,,editorsImpact,,factorConferencesSubscribeFeedback,,for,,editors,,NPG,,services,,Help,,Authors,,and,,Referees,,Librarian,,gateway,,Advertising,,information,,worknpg,,Reprints,,and,,permissions,,NPG,,resources,,Nature,,Reviews,,Nature,,Nature,,Cell,,Biology,,Nature,,Communications,,Nature,,Genetics,,Nature,,Medicine,,Nature,,Methods,,Nature,,Conferences,,Molecular,,Systems,,Biology,,Protocol,,Exchange,,RNAi,,Gateway,,Scitable,,by,,Nature,,Education,,Scientific,,Data,,NPG,,Journals,,by,,Subject,,Area,,Chemistry,,Chemistry,,Drug,,discovery,,Biotechnology,,Materials,,Methods,,&,,Protocols,,Clinical,,Practice,,&,,Research,,Cancer,,Cardiovascular,,medicine,,Endocrinology,,Gastroenterology,,&,,Hepatology,,Methods,,&,,Protocols,,Pathology,,&,,Pathobiology,,Urology,,Earth,,&,,Environment,,Earth,,sciences,,Evolution,,&,,Ecology,,Life,,sciences,,Biotechnology,,Cancer,,Development,,Drug,,discovery,,Evolution,,&,,Ecology,,Genetics,,Immunology,,Medical,,research,,Methods,,&,,Protocols,,Microbiology,,Molecular,,cell,,biology,,Neuroscience,,Pharmacology,,Systems,,biology,,Physical,,sciences,,Physics,,Materials,,by,,A,,-,,Z,,Index,,Extra,,navigation,,Journal,,services,,Sign,,up,,for,,e-alertsRecommend,,to,,your,,libraryWeb,,feeds,,Follow,,us,,on,,Twitter,,Nature,,Reviews,,on,,Facebook,,nature,,jobs,,Faculty,,Positions,,at,,IDG,,/,,McGovern,,Institute,,for,,Brain,,Research,,at,,Peking,,University,,IDG/McGovern,,Institute,,for,,Brain,,Research,,at,,Peking,,University,,Research,,Engineer,,/,,Research,,Scientist,,in,,Renewable,,Energy,,King,,Fahd,,University,,of,,Petroleum,,&,,Minerals,,More,,science,,jobs,,Post,,a,,job,,nature,,events,,KLF,,and,,Sp,,Transcription,,Factors,,in,,Disease,,and,,Regenerative,,Medicine,,07,,August,,2016,,—,,12,,August,,2016,,110,,Carriage,,Way,,,CO,,,United,,States,,Genome,,Variation,,in,,Precision,,Medicine,,2016,,27,,May,,2016,,—,,29,,May,,2016,,Shenzhen,,,Guangdong,,,China,,More,,science,,events,,Advertisement,,Top,,Nature,,Reviews,,Genetics,,ISSN:,,1471-0056,,EISSN:,,1471-0064,,About,,NPG,,Contact,,NPG,,Accessibility,,statement,,Help,,Privacy,,policy,,Use,,of,,cookies,,Legal,,notice,,Terms,,Nature,,jobs,,Nature,,Asia,,Nature,,Education,,RSS,,web,,feeds,,Search:,,,,2016,,Macmillan,,Publishers,,LimitedBadanoTanya,,,Mde,,Leeuw,,,Benjamin,,MThe,authors,examine,current,implementations,in,available,tools,and,show,which,factors,affect,valid,and,successful,detection,of,gene,sets.AbstractFull,TextPDF,(795,KB),Supplementary,information,Main,navigation,Journal,contentJournal,homeAdvance,online,publicationCurrent,issueArchiveWeb,FocusesSupplementsArticle,SeriesMultimediaPosters,Journal,informationGuide,to,Nature,Reviews,GeneticsOnline,submissionGuidelines,for,refereesAbout,the,journalSubscribeFeedback,for,editors,NPG,services,Help,Authors,and,Referees,Librarian,gateway,Advertising,information,worknpg,Reprints,and,permissions,NPG,resources,Nature,Reviews,Nature,Nature,Cell,Biology,Nature,Communications,Nature,Genetics,Nature,Medicine,Nature,Methods,Nature,Conferences,Molecular,Systems,Biology,Protocol,Exchange,RNAi,Gateway,Scitable,by,Nature,Education,Scientific,Data,NPG,Journals,by,Subject,Area,Chemistry,Chemistry,Drug,discovery,Biotechnology,Materials,Methods,&,Protocols,Clinical,Practice,&,Research,Cancer,Cardiovascular,medicine,Endocrinology,Gastroenterology,&,Hepatology,Methods,&,Protocols,Pathology,&,Pathobiology,Urology,Earth,&,Environment,Earth,sciences,Evolution,&,Ecology,Life,sciences,Biotechnology,Cancer,Development,Drug,discovery,Evolution,&,Ecology,Genetics,Immunology,Medical,research,Methods,&,Protocols,Microbiology,Molecular,cell,biology,Neuroscience,Pharmacology,Systems,biology,Physical,sciences,Physics,Materials,by,A,-,Z,Index,Extra,navigation,Journal,services,Sign,up,for,e-alertsRecommend,to,your,libraryWeb,feedsFollow,us,on,Twitter,Nature,Reviews,on,Facebook,nature,jobs,Faculty,Positions,at,IDG,/,McGovern,Institute,for,Brain,Research,at,Peking,University,IDG/McGovern,Institute,for,Brain,Research,at,Peking,University,Research,Engineer,/,Research,Scientist,in,Renewable,Energy,King,Fahd,University,of,Petroleum,&,Minerals,More,science,jobs,Post,a,job,nature,events,KLF,and,Sp,Transcription,Factors,in,Disease,and,Regenerative,Medicine,07,August,2016,—,12,August,2016,110,Carriage,Way,,CO,,United,States,Genome,Variation,in,Precision,Medicine,2016,27,May,2016,—,29,May,2016,Shenzhen,,Guangdong,,China,More,science,events,Top,Nature,Reviews,Genetics,ISSN:,1471-0056,EISSN:,1471-0064,About,NPG,Contact,NPG,Accessibility,statement,Help,Privacy,policy,Use,of,cookies,Legal,notice,Terms,Nature,jobs,Nature,Asia,Nature,Education,RSS,web,feeds,Search:,,2016,Macmillan,Publishers,LimitedHNature,,,Reviews,,,Genetics,,,is,,,on,,,Twitter.The,,articles,,in,,this,,new,,series,,focus,,on,,genetic,,studies,,of,,specific,,diseases,,or,,specific,,processes,,in,,pathogenesisFollow,,,us,,,to,,,keep,,,up-to-date,,,with,,,the,,,latest,,,contentAt,,,the,,,distal,,,evolutionary,,,extreme,,,,comparing,,,the,,,human,,,genome,,,to,,,that,,,of,,,non-mammal,,,vertebrates,,,such,,,as,,,fish,,,has,,,proved,,,to,,,be,,,a,,,powerful,,,filter,,,to,,,prioritize,,,sequences,,,that,,,most,,,probably,,,have,,,significant,,,functional,,,activity,,,in,,,all,,,vertebrates.View,,,At,,,a,,,GlanceTop,,,of,,,pageAuthor,,,affiliations,,,DOE,,,Joint,,,Genome,,,Institute,,,,Walnut,,,Creek,,,,California,,,94598,,,,USA,,,,and,,,Genomics,,,Division,,,,Lawrence,,,Berkeley,,,National,,,Laboratory,,,,Berkeley,,,,California,,,94720,,,,USA.Correspondence,,,to:,,,Edward,,,MThese,,online,,versions,,are,,definitive,,and,,may,,be,,cited,,using,,the,,digital,,object,,identifier,,(DOI).About,,AOPTop,,of,,page16,,May,,2016Research,,HighlightTechnique:,,CRISP(e)R,,genetic,,mapping,,,,PDF,,(164,,KB),,Published,,online:,,16,,May,,2016,,,,doi:10.1038/nrg.2016.68Top,,of,,page09,,May,,2016Research,,HighlightsPopulation,,genetics:,,Bursts,,of,,male-lineage,,expansions,,,,PDF,,(96,,KB),,Published,,online:,,09,,May,,2016,,,,doi:10.1038/nrg.2016.63Cancer,,genomics:,,A,,catalogue,,of,,somatic,,mutations,,,,PDF,,(122,,KB),,Published,,online:,,09,,May,,2016,,,,doi:10.1038/nrg.2016.65Top,,of,,page03,,May,,2016ReviewDeveloping,,and,,evaluating,,polygenic,,risk,,prediction,,models,,for,,stratified,,disease,,preventionNilanjan,,Chatterjee,,,Jianxin,,Shi,,&,,Montserrat,,Garca-Closas,,Published,,online:,,03,,May,,2016,,,,doi:10.1038/nrg.2016.27Common,,diseases,,have,,complex,,aetiology,,involving,,the,,interplay,,of,,genetic,,susceptibility,,and,,environmental,,risk,,factorsHere,,we,review,the,mechanistic,relationship,between,human,disease,phenotypes,and,the,function,of,the,centrosome,,and,describe,some,of,the,newly-appreciated,functions,of,this,organelle,in,animal,cells.View,At,a,GlanceTop,of,pageAuthor,affiliations,McKusick-Nathans,Institute,of,Genetic,Medicine,,John,Hopkins,University,,533,Broadway,Research,Building,,733,N.McPherson,,,&,,,WFurther,,,they,,highlight,,future,,directions,,for,,the,,study,,of,,gene,,losses,,and,,their,,relevance,,in,,evolutionary,,biology,,and,,biomedicine.AbstractFull,,TextPDF,,(734,,KB),,Supplementary,,informationTop,,of,,pageAbout,,AOPUntil,,print,,versions,,of,,AOP,,papers,,are,,published,,,they,,should,,be,,cited,,in,,the,,style,,"Nature,,Reviews,,Genetics,,AOP,,,published,,online,,day,,month,,year;,,doi:10.1038/nrgXXX"Broadway,,Baltimore,,Maryland,21205,,USAAkbarip146,,,,,,doi:10.1038/nrg.2015.34RNA-guided,,,endonucleases,,,have,,,the,,,potential,,,to,,,revolutionize,,,the,,,engineering,,,of,,,synthetic,,,gene,,,drives,,,,which,,,may,,,be,,,particularly,,,useful,,,for,,,the,,,control,,,of,,,vector-borne,,,diseasesNeale,,,,Tom,,,Heskes,,,&,,,Danielle,,,Posthumap353,,,,,,doi:10.1038/nrg.2016.29This,,,Analysis,,,provides,,,a,,,statistical,,,evaluation,,,of,,,the,,,core,,,structure,,,inherent,,,to,,,all,,,gene-set,,,analysesAnalysis,,,of,,,most,,,human,,,proteins,,,and,,,nucleic,,,acids,,,is,,,important,,,in,,,order,,,to,,,decode,,,the,,,complex,,,networks,,,that,,,are,,,likely,,,to,,,underlie,,,many,,,common,,,diseasesHere,,,the,,authors,,describe,,methods,,for,,building,,and,,evaluating,,models,,for,,the,,prediction,,of,,disease,,risk,,based,,on,,information,,from,,genetic,,testing,,and,,environmental,,factors,,,and,,use,,case,,studies,,to,,illustrate,,the,,potential,,of,,such,,models,,in,,the,,prevention,,of,,diseasesNobrega1,,&,,Edward,,MLangeJohan,GobomLajos,NyarsikHarald,SeitzHans,Lehrachmore,authors,of,this,article,nature,jobs,Gastroenterologist,Loyola,University,Chicago,Grand,stage,for,great,players:,CCID,recruiting,principal,investigators,The,Collaborative,Innovation,Center,for,Diagnosis,and,Treatment,of,Infectious,Diseases,(CCID),More,science,jobs,Post,a,job,nature,events,KLF,and,Sp,Transcription,Factors,in,Disease,and,Regenerative,Medicine,07,August,2016,—,12,August,2016,110,Carriage,Way,,CO,,United,States,Genome,Variation,in,Precision,Medicine,2016,27,May,2016,—,29,May,2016,Shenzhen,,Guangdong,,China,More,science,events,Advertisement,Top,Nature,Reviews,Genetics,ISSN:,1471-0056,EISSN:,1471-0064,About,NPG,Contact,NPG,Accessibility,statement,Help,Privacy,policy,Use,of,cookies,Legal,notice,Terms,Nature,jobs,Nature,Asia,Nature,Education,RSS,web,feeds,Search:,,2016,Macmillan,Publishers,LimitedThe,,,authors,,,examine,,,current,,,implementations,,,in,,,available,,,tools,,,and,,,show,,,which,,,factors,,,affect,,,valid,,,and,,,successful,,,detection,,,of,,,gene,,,setsMcPherson,,&,,WRubin1,,About,,the,,authorsTop,,of,,pageAbstractAnnotators,,of,,the,,human,,genome,,are,,increasingly,,exploiting,,comparisons,,with,,genomes,,at,,both,,the,,distal,,and,,proximal,,evolutionary,,edges,,of,,the,,vertebrate,,treeArticle,,,series,,,on,,,Regulatory,,,elements,,,The,,,articles,,,in,,,this,,,series,,,discuss,,,recent,,,views,,,on,,,regulatory,,,elements,,,,including,,,their,,,role,,,in,,,evolution,,,and,,,the,,,function,,,of,,,chromatin,,,modifications,,,,as,,,well,,,as,,,methods,,,to,,,study,,,these,,,important,,,regions,,,of,,,the,,,genomepartner,of,AGORA,,HINARI,,OARE,,INASP,,ORCID,,CrossRef,,COUNTER,and,COPE,Rubin1,Email:emrubinlbl.gov,Top,of,page,MORE,ARTICLES,LIKE,THIS,These,links,to,content,published,by,NPG,are,automatically,generated.REVIEWSApproaches,to,comparative,sequence,analysis:,towards,a,functional,view,of,vertebrate,genomesNature,Reviews,Genetics,Review,(01,Apr,2008)Conserved,non-genic,sequences,???,an,unexpected,feature,of,mammalian,genomesNature,Reviews,Genetics,Perspective,(01,Feb,2005)See,all,16,matches,for,ReviewsNEWS,AND,VIEWSResearch,notesNature,Genetics,News,and,Views,(01,Aug,2003)RESEARCHIn,vivo,enhancer,analysis,of,human,conserved,non-coding,sequencesNature,Letters,to,Editor,(23,Nov,2006)Mammalian,ultraconserved,elements,are,strongly,depleted,among,segmental,duplications,and,copy,number,variantsNature,Genetics,Letter,(01,Oct,2006)See,all,21,matches,for,Research,Main,navigation,Journal,contentJournal,homeAdvance,online,publicationCurrent,issueArchiveWeb,FocusesSupplementsArticle,SeriesMultimediaPosters,Journal,informationGuide,to,Nature,Reviews,GeneticsOnline,submissionGuidelines,for,refereesAbout,the,journalSubscribeFeedback,for,editors,NPG,services,Help,Authors,and,Referees,Librarian,gateway,Advertising,information,worknpg,Reprints,and,permissions,NPG,resources,Nature,Reviews,Nature,Nature,Cell,Biology,Nature,Communications,Nature,Genetics,Nature,Medicine,Nature,Methods,Nature,Conferences,Molecular,Systems,Biology,Protocol,Exchange,RNAi,Gateway,Scitable,by,Nature,Education,Scientific,Data,NPG,Journals,by,Subject,Area,Chemistry,Chemistry,Drug,discovery,Biotechnology,Materials,Methods,&,Protocols,Clinical,Practice,&,Research,Cancer,Cardiovascular,medicine,Endocrinology,Gastroenterology,&,Hepatology,Methods,&,Protocols,Pathology,&,Pathobiology,Urology,Earth,&,Environment,Earth,sciences,Evolution,&,Ecology,Life,sciences,Biotechnology,Cancer,Development,Drug,discovery,Evolution,&,Ecology,Genetics,Immunology,Medical,research,Methods,&,Protocols,Microbiology,Molecular,cell,biology,Neuroscience,Pharmacology,Systems,biology,Physical,sciences,Physics,Materials,by,A,-,Z,Index,Extra,navigation,This,issueTable,of,contentsPrevious,abstractNext,abstract,Article,tools,Full,text,Download,PDF,Send,to,a,friendCrossRef,lists,89,articles,citing,this,articleScopus,lists,177,articles,citing,this,articleExport,citationRights,and,permissions,Order,commercial,reprints,Article,navigationAuthor,affiliationsArticle,viewAt,a,glanceFigures,and,tablesAbout,the,authorsSearch,Pub,Med,for,the,following,terms:Dario,BoffelliMarcelo,ACURRENT,,,ISSUE,,,Viewpoint,,,RNA,,,modifications:,,,what,,,have,,,we,,,learned,,,and,,,where,,,are,,,we,,,headed?,,,Michaela,,,Frye,,,,Samie,,,RRich,,&,,Soumya,,Raychaudhurip160,,,,doi:10.1038/nrg.2015.33Genome-wide,,approaches,,have,,advanced,,the,,study,,into,,mechanisms,,triggering,,autoimmunitypartner,,of,,AGORA,,,HINARI,,,OARE,,,INASP,,,ORCID,,,CrossRef,,,COUNTER,,and,,COPE,,This,,,Review,,,discusses,,,the,,,considerable,,,technical,,,challenges,,,of,,,amplifying,,,and,,,interrogating,,,genomes,,,from,,,single,,,cells,,,,emerging,,,innovative,,,solutions,,,and,,,various,,,applications,,,in,,,microbiology,,,and,,,human,,,disease,,,,in,,,particular,,,in,,,cancer.AbstractFull,,,TextPDF,,,(649,,,KB),,,Main,,,navigation,,,Journal,,,contentJournal,,,homeAdvance,,,online,,,publicationCurrent,,,issueArchiveWeb,,,FocusesSupplementsArticle,,,SeriesMultimediaPosters,,,Journal,,,informationGuide,,,to,,,Nature,,,Reviews,,,GeneticsOnline,,,submissionGuidelines,,,for,,,refereesAbout,,,the,,,journalSubscribeFeedback,,,for,,,editors,,,NPG,,,services,,,Help,,,Authors,,,and,,,Referees,,,Librarian,,,gateway,,,Advertising,,,information,,,worknpg,,,Reprints,,,and,,,permissions,,,NPG,,,resources,,,Nature,,,Reviews,,,Nature,,,Nature,,,Cell,,,Biology,,,Nature,,,Communications,,,Nature,,,Genetics,,,Nature,,,Medicine,,,Nature,,,Methods,,,Nature,,,Conferences,,,Molecular,,,Systems,,,Biology,,,Protocol,,,Exchange,,,RNAi,,,Gateway,,,Scitable,,,by,,,Nature,,,Education,,,Scientific,,,Data,,,NPG,,,Journals,,,by,,,Subject,,,Area,,,Chemistry,,,Chemistry,,,Drug,,,discovery,,,Biotechnology,,,Materials,,,Methods,,,&,,,Protocols,,,Clinical,,,Practice,,,&,,,Research,,,Cancer,,,Cardiovascular,,,medicine,,,Endocrinology,,,Gastroenterology,,,&,,,Hepatology,,,Methods,,,&,,,Protocols,,,Pathology,,,&,,,Pathobiology,,,Urology,,,Earth,,,&,,,Environment,,,Earth,,,sciences,,,Evolution,,,&,,,Ecology,,,Life,,,sciences,,,Biotechnology,,,Cancer,,,Development,,,Drug,,,discovery,,,Evolution,,,&,,,Ecology,,,Genetics,,,Immunology,,,Medical,,,research,,,Methods,,,&,,,Protocols,,,Microbiology,,,Molecular,,,cell,,,biology,,,Neuroscience,,,Pharmacology,,,Systems,,,biology,,,Physical,,,sciences,,,Physics,,,Materials,,,by,,,A,,,-,,,Z,,,Index,,,Extra,,,navigation,,,Journal,,,services,,,Sign,,,up,,,for,,,e-alertsRecommend,,,to,,,your,,,libraryWeb,,,feedsFollow,,,us,,,on,,,Twitter,,,Nature,,,Reviews,,,on,,,Facebook,,,nature,,,jobs,,,Grand,,,stage,,,for,,,great,,,players:,,,CCID,,,recruiting,,,principal,,,investigators,,,The,,,Collaborative,,,Innovation,,,Center,,,for,,,Diagnosis,,,and,,,Treatment,,,of,,,Infectious,,,Diseases,,,(CCID),,,Postdoctoral,,,positions,,,in,,,Clinical,,,Bioinformatics,,,at,,,the,,,Imagine,,,Institute,,,for,,,Genetic,,,diseases,,,Imagine,,,Institute,,,for,,,Genetic,,,Diseases,,,More,,,science,,,jobs,,,Post,,,a,,,job,,,nature,,,events,,,KLF,,,and,,,Sp,,,Transcription,,,Factors,,,in,,,Disease,,,and,,,Regenerative,,,Medicine,,,07,,,August,,,2016,,,—,,,12,,,August,,,2016,,,110,,,Carriage,,,Way,,,,CO,,,,United,,,States,,,Genome,,,Variation,,,in,,,Precision,,,Medicine,,,2016,,,27,,,May,,,2016,,,—,,,29,,,May,,,2016,,,Shenzhen,,,,Guangdong,,,,China,,,More,,,science,,,events,,,Top,,,Nature,,,Reviews,,,Genetics,,,ISSN:,,,1471-0056,,,EISSN:,,,1471-0064,,,About,,,NPG,,,Contact,,,NPG,,,Accessibility,,,statement,,,Help,,,Privacy,,,policy,,,Use,,,of,,,cookies,,,Legal,,,notice,,,Terms,,,Nature,,,jobs,,,Nature,,,Asia,,,Nature,,,Education,,,RSS,,,web,,,feeds,,,Search:,,,,,,2016,,,Macmillan,,,Publishers,,,LimitedWilmer,Eye,Institute,,Johns,Hopkins,University,,Baltimore,,Maryland,21205,,USA.Correspondence,to:,Nicholas,Katsanis1,2,Email:katsanisjhmi.edu,Top,of,page,MORE,ARTICLES,LIKE,THIS,These,links,to,content,published,by,NPG,are,automatically,generated.REVIEWSCilia,and,centrosomes:,a,unifying,pathogenic,concept,for,cystic,kidney,disease?Nature,Reviews,Genetics,Review,(01,Dec,2005)See,all,20,matches,for,ReviewsNEWS,AND,VIEWSHuman,disease:,the,centrosome,connectionNature,Cell,Biology,News,and,Views,(01,May,2004)Cilia,put,a,brake,on,Wnt,signallingNature,Cell,Biology,News,and,Views,(01,Jan,2008)See,all,8,matches,for,News,And,ViewsRESEARCHThe,Bardet-Biedl,protein,BBS4,targets,cargo,to,the,pericentriolar,region,and,is,required,for,microtubule,anchoring,and,cell,cycle,progressionNature,Genetics,Article,(01,May,2004)Disruption,of,the,basal,body,compromises,proteasomal,function,and,perturbs,intracellular,Wnt,responseNature,Genetics,Article,(01,Nov,2007)See,all,49,matches,for,Research,Main,navigation,Journal,contentJournal,homeAdvance,online,publicationCurrent,issueArchiveWeb,FocusesSupplementsArticle,SeriesMultimediaPosters,Journal,informationGuide,to,Nature,Reviews,GeneticsOnline,submissionGuidelines,for,refereesAbout,the,journalSubscribeFeedback,for,editors,NPG,services,Help,Authors,and,Referees,Librarian,gateway,Advertising,information,worknpg,Reprints,and,permissions,NPG,resources,Nature,Reviews,Nature,Nature,Cell,Biology,Nature,Communications,Nature,Genetics,Nature,Medicine,Nature,Methods,Nature,Conferences,Molecular,Systems,Biology,Protocol,Exchange,RNAi,Gateway,Scitable,by,Nature,Education,Scientific,Data,NPG,Journals,by,Subject,Area,Chemistry,Chemistry,Drug,discovery,Biotechnology,Materials,Methods,&,Protocols,Clinical,Practice,&,Research,Cancer,Cardiovascular,medicine,Endocrinology,Gastroenterology,&,Hepatology,Methods,&,Protocols,Pathology,&,Pathobiology,Urology,Earth,&,Environment,Earth,sciences,Evolution,&,Ecology,Life,sciences,Biotechnology,Cancer,Development,Drug,discovery,Evolution,&,Ecology,Genetics,Immunology,Medical,research,Methods,&,Protocols,Microbiology,Molecular,cell,biology,Neuroscience,Pharmacology,Systems,biology,Physical,sciences,Physics,Materials,by,A,-,Z,Index,Extra,navigation,This,issueTable,of,contentsPrevious,abstractNext,abstract,Article,tools,Full,text,Download,PDF,Send,to,a,friendCrossRef,lists,96,articles,citing,this,articleScopus,lists,163,articles,citing,this,articleExport,citationRights,and,permissions,Order,commercial,reprints,Article,navigationAuthor,affiliationsArticle,viewAt,a,glanceFigures,and,tablesAbout,the,authorsSearch,Pub,Med,for,the,following,terms:Jose,L 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